Frankly, no. Samus is one of my favorite characters and without her Metroid is pretty generic sci-fi.
Well the rumor is you play as Samus through the prelude. After a kick ass fight with Ridley, you awaken on a derelect vessel. As the view transitions from 1st person to 3rd we see we are in control of Sylux.Sure. I secretly hope MP4 stars Sylux instead of Samus just to see everyone's reaction.
I know it isn't exactly what you are asking, OP, but Rogue Dawn is an insanely good Metroid rom hack where Samus is not the main character. Highly recommend.
Seems like people have already forgotten about Federation Force... Samus is the series for me to be honest and it feels like that removing her would strip away from being as powerful as you possibly can be in the Metroid series.
Huh, interesting. What rumor?Well the rumor is you play as Samus through the prelude. After a kick ass fight with Ridley, you awaken on a derelect vessel. As the view transitions from 1st person to 3rd we see we are in control of Sylux.
It was a MGS2 joke.