It's Wii Sports hands down.
Like, my grandma and grandpa played Wii Sports. My mom and dad, who were anti video games, played Wii Sports. It was brought into senior centers, rehabs, youth groups, etc . . . All because it was one of the most easy to pick up games of all time and it was a blast to play with others.
I bet that if you broke down the poll results the majority of those picking Astro Boy are <25.
Results are closer than I thought