Honestly, I can see the Star Trek characters being baffled by the anime cliches and just deciding to treat them like weird aliens of the week.Star Trek Discovery x Trails of Cold Steel III...
Well, Rean is a Gary Stu and Burnham has been accused of being a Mary Sue, so... they would get along well. But man, I don't want to imagine a Star Trek full of anime clichés. Regardless, the USS Discovery would be a great asset to Rean and his companions.
Honestly, I can see the Star Trek characters being baffled by the anime cliches and just deciding to treat them like weird aliens of the week.