MY current two? One does, one does not (we're working on him but he really doesn't trust being picked up and if he's not really in the mood to tolerate it he will bite to get down). Previous cats? My favorite cat ever loved to be picked up unless she really wasn't in the mood (I don't think I've ever had a cat that didn't have moods where tehy didn't want to be picked up but honestly, would you always like some one to stop what you were doing and pick you up all the time). My siamese was way too timid/afraid but I got her by the end to let me pick her up and put her on my lap... and occasionally pick her up and cuddle her (She was a real scaredy cat, took me three months to get her to let me pet her). My tabby didn't mind but he wasn't that super affectionate of a cat, he more preferred hanging out where you were rather than cuddling. But you could pick him up and he didn't seem to care too much. My three cats growing up didn't seem to mind it (But I never tried to pick them up and just cuddle them. Just pick them up and put them on my lap or move them somewhere).
So I'd say half and half...a little mroe than half at least didn't mind it.