For reference, the preferred versions of American Dad for speed running are for US Gamecube, US Xbox and Xbox 360. PAL versions don't have a 60Hz option so they run 17% slower. The US PS2 version has a tendency to hardlock when some of the exploits are used - don't try to car skip on the PS2 game.
The PS3 version can get bad framerate dips and slowdown during the intro, which is no bueno. If you've ever seen the DF Retro video on American Dad, you'll know what I'm talking about.
The Wii game is based off the GC version but has a few fixes that make it less friendly to people wanting to glitch run. But there's some interesting stuff being found in that version that could lead to it's own % ranking in the future.