Usually it's nothing too major, a weapon here or there for example, but sometimes it's very significant and can completely change the game, in my case because the handmaiden isn't a possibile companion if you play as a female in knights of the old republic 2 I never knew she was playable for years, sad too because she's easily the more interesting of the gender specific companions and imo the most interesting of them all (also odd considering female Jedi is the "canon" protagonist as far as lore is concerned.)
Luckily mods on pc can get past that little issue, but some are not so easily fixed.
Luckily mods on pc can get past that little issue, but some are not so easily fixed.