DOOM was definitely made with portable mode as the primary focus. Whether docked or not, it runs at 720p, the native resolution of the Switch's display. That means it looks really great in handheld mode, but when docked things start to look a bit muddy and blurry. We didn't find that this caused issues for us with the game, but it was noticeable. What did cause some problems were the frame rate and the audio. DOOM is a beautiful game, but that beauty comes with a price tag. When enemies got a bit too dense on screen or when large numbers of particle effects were going on at once, the frame rate took a major hit, becoming noticeably choppy. If we had to guess, we'd say the frame rate can occasionally drop into the teens.
These drops didn't happen often, but they're there all the same. It seems a few areas are problem spots in the game, but we found it was easiest to reproduce these issues in arcade mode, where more of everything seems to be happening. Audio issues were far more consistent in our experience. During glory kills we would sometimes experience audio not playing at all, and in some levels we noticed problems so severe the game would need to be restarted. Audio would at times be very low and sound effects would instead trigger a popping sound. We're hopeful that these faults will be addressed in a patch.