Got my After Hours edition on Saturday and since then I've managed to get as far as Chapter 4, playing on Hard. Really enjoying the game, love the seamless nature of being able to enter the arcades and bars and restaurants without having a loading screen. Everything feels so streamlined compared to 0 and Kiwami (only games I've played, started with 0), up to and including the completion list. I've 100%ed the completion list in 0 and Kiwami and will probably do the same with 6, although it appears from the trophies that you don't need to do everything for the trophy this time around.
I've had one game over so far because I just don't have any money to heal myself or buy medicine - I've been on 25 Yen for a while now. In Kamurocho enemies would drop money on occasion but
random encounters don't seem to drop any money at all - eventually I got to a story encounter with hardly any health and just had to let myself die so I could continue with a full HP bar. At least I know to be conservative with my money at the beginning of a Legend playthrough! Presumably some sort of revenue stream will open up later in the story.