I've seen them brought up elsewhere, too, although maybe it's still prominent here.
Perwsonally I'm not that into most of the stuff they do. I've watched a few Quick Looks over the years, seen parts of their E3 streams, and tried (and failed) getting through their Persona 4 and Deadly Premonition Endurance Runs, since those seemed to be their most popular content at the time. They're not bad, mind you, I just don't find them particularly interesting or as funny as some people do.
The one series of theirs I do keep following is Ranking of the Fighters, because I love learning about some of the forgotten or lesser konwn video games, and they frame that show in a pretty fun way. I'm not up to date with that series either, but that doesn't bother me.
Recently there was at thread here for Era's Top OK Games, and if there was a Top OK VG Websites, or something similar, Giant Bomb would be my submission.