Really? I'd say Ayesha is absolutely an otome. What disqualifies it for you?
Mmm I guess DLC swimsuits?
Though yeah, I got back into Atelier because I was told the Dusk series cut back on the fanservice and Ayesha was a pleasant experience so I'll concede that point. The Ayesha pre release OT seemed more jazzed about the little witch girl's animations so that might've colored my impressions too. I don't play otome games so can't say I know what that vibe is but I don't really get a romantic tone to the interactions. Not even in a wink wink shipping tease.
Oh actually I recall a couple events now. It seemed like typical anime game stuff though, like a Tales of skit.
Edit: I guess what I'm trying to say is that I appreciate that Ayesha cut back on the usual side eye that comes with niche anime games, it's sandwiched between Arland, the more fanservice heavy trilogy, and Mysterious, with its outfits and CGs. The other games in Ayesha's trilogy, Eschalogy and Shallie, trend more toward that direction too. The limited edition of Nelke came with a body pillow and Lulua is a sequel to Arland and Ryza is Ryza.
There's not much quite like Atelier, with its small scale conflicts and non-romantic goal oriented female protagonists and I'm glad it exists but the series has felt like it was male oriented for a while now and for the foreseeable future. Ayesha was an outlier.