It's probably my favorite game on the 3DS, but I have to echo other lefties here on the gimped controls. It is only by sheer force of will that I was able to see that wonderful experience through to the end.
I desperately wanted to spend more time pushing harder difficulties, but the controls were such a wall for me that I eventually gave up replaying chapters.
If I'm not mistaken, the game originally wasn't even going to have all of the control options it shipped with. ABXY movement was already awkward as hell with your right hand as a lefty, but if you preferred to use the circle pad as an aiming reticule like me (instead of the stylus), you were also locked out of dodging properly. And no matter how comfortable you got with the on-foot control scheme of your choice, you had to use the same controls for the flight segments which were quite frankly a nightmare with ABXY movement.
I haven't played since it came out, so I could be misremembering a few things, but I definitely know the controls never stopped being an issue for me. :(