LolEverybody knows it's Mario & Luigi, but the hipsters will throw out every duo you forgot about until you read their response.
Of the available options in your poll, I'd go with Sonic and Tails easily. But the true correct answer isn't an option, shamefully:
Any duo that includes Moriarty couldn't possibly be the best duo.
Came for Dante and Vergil, stayed for this.
Everybody knows it's Mario & Luigi, but the hipsters will throw out every duo you forgot about until you read their response.