I think the reapers were some of the coolest and scariest antagonists you could find in gaming, due to their sheer technological advantages and overwhelming numbers. So which game universe, do you think could handle or repel the reaper invasion better than Mass Effect Universe?
My choice would the be the Earth Defense Force Universe
Insanely OP guns, mechs of all shapes, utility and sizes, and are so used to being invaded by alien species and reverse engineering their tech.