Currently, MH: Rise, but only because I'm most confident about that game versus others at actually delivering. Alongside it is FF7 Remake Intergrade - I bought it Day One on PS4, failed to play it, and now eagerly anticipating ACTUALLY playing it with all the improvements. Mass Effect Trilogy is a shoe-in, too.
Not sure if it counts, but EndWalker's trailer got me to try an MMO for the first time in a decade - and in a month I've put more time into FFXIV than I have just about any other game in the last few years in such a short amount of time. Just about to start HW. If this keeps my interest, then absolutely EW... but who knows if I'll stick with it.
I'd really, really love Halo Infinite to go back to form - so I've got a watchful eye on it.
I'm also really excited for Fantasium - I'm... worried... about mobile and JRPG grind fests. But I adore how it looks.
BotW2 would easily trump all, but I have no confidence we'll see it this year.