I only hope that they don't change the feeling of exploration in the game. I know many people dislike pawns (especially the banter), but I quite enjoy it. Most of the time i'm not paying a whole lot of attention to what they are saying in combat (mostly looking for visual cues), but outside of combat it is nice to have the feeling like you're not alone on your journey. The pawns are a great addition to Dragon's Dogma and help to enhance the D&D experience that Itsuno was aiming for. Not to say that there isn't room for improvement, of course.
Without a doubt, the Warrior class needs to be further fleshed out. Only having access to three skill slots essentially turned the class into jump attacking most of the game.
Given the team's experience with DMC, I think it would be interesting to include more abilities that have synergy with each other and can combo into other abilities. An example of this in the original game is Leaping Stone into Brain Splitter for the Strider class. More of that would be great.
People have touched on this already, but inventory management is a real chore, as is carry weight.
Stamina should not be consumed while running outside of combat.
More Bluemoon Towers, Everfalls, and Bitterblack Isles (those places really stick out to me for the atmosphere, sense of wonder, and level design).
Scrap escort quests.
tl;dr
QoL changes and more Dragon's Dogma.