I played it blind a week ago and whew, it definitely left a big impression. I had already heard about the cannery section which was a shame since it somewhat diminished the impact, but it's still a genius combination of gameplay and narrative. The most memorable stages were probably the first one with the shapeshifting girl (the ending is really disturbing) and the bathtub sequence which left me in tears.
The ending is a bit anti-climactic and it left me with a "wait that's it?" feeling, but after musing about the game and how the titular character contributed to the "curse", the story suddenly became a lot more insidious and haunting. These layers the story contains firmly put it atop the narrative game genre for me, and it's an experience I'll likely never forget.