False King with arrows through the fog gate, I have no shame.
I was just about to mention this one. Absolutely disgusting way to win, but I'll take it.
Honorable mentions: Mortal Kombat SNES had a glitch in the game logic where the CPU would simply fail to block jump kicks done from a specific distance.
You can double flawless victory every single opponent in the game Goro included this way.
Double Dragon NES had a glitch in mission 2 where the stage boss (Chin) can be defeated just by going back down the ladder used to reach him. The game despawns him and registers him as killed. I don't know *anyone* who beats this guy legitimately.
Blaster Master NES has a glitch that works on numerous bosses- throw a grenade at the boss and pause the game. It will register the boss being hit by grenades continuously through the pause. Weirdly Mega Man 1 has a similar glitch using the Elec Beam.
About 2 casts of the healing spell will kill the final boss (!!!) of FF mystic quest, granting that game the all time title of easiest RPG ever. It's not even a glitch. This was definitely intentional.
Not really a "glitch" but the nihopalaoa in FFXII is hilariously broken and trivializes a good chunk of the hunts, bosses, and higher level regular enemies if a player understands what it does. That item reverses the effect of any items used by the wearer. It appears nigh useless (because healing potions now damage you) but a Remedy thrown by someone wearing that thing (assuming they've unlocked remedy lore 1,2, and 3) will immediately inflict Poison/Slow/Blind/Silence/Sleep/Sap/Immobilize/Disable/Petrify/Confuse/Oil/Stop/Doom/Disease simultaneously AND it will hit the target successfully 100% of the time as items can't be evaded.
The "Trickster" hunt becomes incredibly easy with this trick, as that boss (usually difficult to hit and locate) becomes immobilized immediately allowing the party to devastate it at leisure.
The niho will also turn Phoenix Down into unavoidable one hit kill items for anything not immune to Death.
It becomes less useful in the endgame as most serious threats have heavy status immunity but you'll cruise through 2/3 of that game until then.