Depends on the route.
Usually I don't mind, but the long way to Ornstein&Smough really got on my nerves.
Agreed. Mostly they didn't bother me, but I found the routes to Martyr Logarius and Shadow of Yharnam somewhat annoying, as there was a higher chance of getting hit along the way, and IIRC there weren't Blood Vials to be found before Logarius, unlike say Mergo's Wet Nurse.