Some additional info:
1) While the combat and all the systems about weapons are in no way finished, in general the plan right now is to have melee weapon degradation, and guns to be somewhat discardable - after a few reloads you'll need to find a new one, so no more 30 magazines of assault rifle ammo and burninator fuel.
2) There will be a Blood Heal, with which you can regenerate your health at the press of a button, but it does not count as a Discipline.
3) Blood Buff/Rouse will also be somewhat always active - i.e. stuff like climbing walls and easily overpowering mortals is due to the innate abilities of a vampire.
4) Skills will still have dots in them and all, but as with everything else they are trying to move away from the BL1 "10% buff" school of design. So the higher you go even in your normal skills, the more options and abilities open up.