Yes and no. While CDPR does ensure a game runs on modern systems when preparing it for release, post-release support rests with the publisher, which can and has lead to cases of incompatibility. Worms 2, for example, doesn't work on Windows 10 at all without workarounds.
Yeah, I bought The Testament of Sherlock Holmes recently and the GOG version has exactly the same problem on modern systems as the Steam version. There's high chance that it'll crash when saving, taking all your progress up to that point with it. This game isn't even that old either, it was released six years ago.