I've heard a lot of people write off Animal Crossing because the game's release timing played such a role in its cultural impact, but I think that's exactly why it should be game of the year (apart from the fact that it's an exquisitely crafted dopamine machine). It is the game of the year in literal terms -- the game that defined 2020. That said, it is definitely not the multiplayer or online game of the year, unless we're speaking strictly culturally and totally disregarding mechanics.
It's also so good to see Hades nominated as were it not for AC, that would be my personal game of the year. But given the culture of the Game Awards, Last of Us or Ghosts will take it regardless of what I think.
And relegating independent games to their own categories is getting progressively dumber each year. Most of the noms for art direction, narrative and music are laughable apart from the token indie nods -- the indie space absolutely owns those categories.
Finally, someone throw Warframe a bone for ongoing game. That game is the antidote to all the things people hate about games-as-service, and Digital Extremes manages to do it without being shitheads like a lot of other companies on that list.