Just wrapped up the Platinum a month or two ago, so it's all pretty fresh still. Despite really wanting to rock one-handed and staves, single-rigged turned out to be the best way to go, IMO. Specifically the kind with high Impact. Stagger for days, and that sliding dash attack!
Blocking is fairly useless early on, but those early enemies have simple attack patterns that are easy to exploit. Late game enemies, and once you've got an implant that converts blocks to energy? Blocks can really save your ass later on.
I found choice in armor to be probably the least important decision. Run with whatever floats your boat. I used Lynx for the attack speed bonus for most of the run, switching over to some DLC sets in the late game. Barely felt the change. Weapon and implants are SOOOOOO much more important. Once you start getting them, consider armor sets that boost Impact even more. Then your single-rigged weapons will basically act like heavies.
And on that note, both story DLCs have some good gear to get. The Good, The Bad, and The Augmented, in particular, have utterly game-breaking implants. You'll need to massively power-level to equip them, though.