Yep, the sacks. They basically teleport in, usually in large packs, so no matter which direction I roll I end up hit by at least one. Then usually Gorefist catches up to me and swipes me, boom, dead. Using the environment does jack shit to slow him down. The sacks come out of nowhere (I'm not getting a sound cue?) so avoiding them is next to impossible.
I have the Drifter gear set, and I have all the starting long guns, the repeater pistol, and the submachine gun. I have the shotgun upgraded the most. I have zero scrap--blew what little I had left buying bandages to stop Gorefist's bleeding effect from his sword.
Oh, and he has the Regenerator mod but that's not really an issue (for me).
The Regenerator modifier simply extends the fight, which CAN be an issue. But it's definitely not the worst modifier for that fight. Agreed.
If you need more Scrap and Iron, don't be afraid to hit up some jolly co-op. You'll get tons by helping out others via joining public games.
You may even wind up with better weapons, more traits, definitely more trait levels, etc.
The exploding nut sacks have some very obvious audio cues, so you may want to fiddle with the in-game volume sliders if that's an issue.
If you can reliably one- or two-shot the nutsacks with one of your two weapons, that's definitely the best way to go. If not, use the audio cues to time your dodges, and try to avoid using the camera to line them up. You'll probably need a decent surround sound set up for this. (Unlike a game like Destiny, I find the situational virtual 3D audio when using a headset with Remnant to be fairly unreliable for pinpointing their position using only audio cues. Destiny is excellent. Don't know what witchery they use).
There's a couple of different strats depending on your loadout, capacity to quickly eliminate the nutsacks, and your overall situational awareness.
Decent surround sound system? Try to dodge away from the explosions? Stuck with a headset or stereo sound? Try to level up one of your weapons so they can nuke the sacks with one or two shots.
If you're playing solo, you MAY find it easier to fight up on the catwalk above the main arena. There'll be less room to avoid Gorefist (but you should be using your roll's i-frames to negate his attacks anyway, not actually trying to physically avoid them), but the nutsacks can only approach from two directions, which makes managing them (and chain-exploding them) much easier. And speaking of Gorefist, I have the most success actually rolling INTO his attacks, not away from them. ESPECIALLY for his running/charging swing. His swing combo can be trickier.
I feel like if you can get this down, you'll be well-prepared to learn most of the rest of the bosses. It's definitely a bit of a difficulty spike, because the game is basically throwing you into the deep end of the boss pool and demanding that you learn how to swim without any real lead-up or practice. (I still think a Mangerl fight with no modifiers should be a guaranteed first boss for all fresh, new runs. It's more forgiving and does at least a good a job of teaching you how to manage adds and focus DPS when the opportunity avails itself. But maybe that's just me).