My PS5 completely removed my install of 2K21. I played it earlier, and a short clip was even generated when I got a trophy. Got back on later and the entire game was completely gone, with an arrow next to it to redownload.
Then the system randomly shut off. It came back up and was talking about the extended storage that had my PS4 games on it, was corrupted and needed to be repaired. Seen this a bunch on PS4. Went through the process and then the screen sat blank for 5 minutes before I finally turned the system off, and it wouldn't turn back on.
Removed the external HDD and it came back up. I've seen others complain about external HDDs too. At this point use at your own risk, I've removed mine until they offer their "stability updates".