I don't think any of them are irredeemable, and with more time the associations will lessen.
Pepe still gives me gut reaction red flag feelings, but I have friends who use it and I know the original artist has pushed back real hard against that connection, plus seeing the response here solidifies in my mind that it'll continue to move away from being an alt-right symbol. The A-OK hand on its own will forever just be that Pacha / Emperor's New Groove meme to me and the alt-right bullshit ain't gonna change that -- however context matters. Like... if I see some dude doing it 'subtly' in a photo -- against his leg or on a wall or something, that is 100% obviously an alt-right sign. Nobody uses it that way except them, so I don't think it makes the hand symbol in general a problem. And the hat I really expect to fade out of fashion in another 5-10 years, maybe. Like 'Make America Great Again' is 100% tainted forever, but red hats? Nah. It may make you gut-clench now, but fashion is especially fickle and red ball caps have so many other associations I just really do not think the MAGA one is gonna stick for all that long. I expect it to maybe flare up again if Trump tries to run again, but that it'll otherwise die with him.