The biggest thing for me now (at 38) is mostly healing speed and how crackly my knees are.
Knees are from soccer, so not too surprised given that abuse. They don't hurt or anything, just make noise.
Healing speed is just that I don't bounce back quite as fast. My hangovers are awwwwful now though and take less to trigger, age + HRT double whammy there. Like I can easily get one if I don't hydrate sufficiently even if I barely get buzzed.
Otherwise I'm not too far off what I was at 25. Eyesight has been consistent since hitting adulthood to the point my script hasn't changed in a decade, weight has never been an issue (pre HRT I capped out at ~182 at 5'11" at two points in my life, technically right at 'Overweight' line but I had a lot of lean muscle going on, dropped down 20+ lbs since Jan 1st, 2020), still 0 cavities lifetime (genetics more than anything). My memory is still strong, have managed to avoid carpel tunnel, and so on. Less endurance but I could probably fix that with some active training. Cholesterol still good, BP is down from peak (even pre HRT).
My back has done a Benjamin Button - was bad from get go in 20s, then somewhat better via better chairs and bed, then about 4 years ago I threw it out playing soccer. Throwing it out was the best thing ever for it apparently since I was forced to properly care for it and in the years since it's felt better than it ever has as an adult. For soccer I took up a better warm up/cool down regiment (that helped all over), worked on posture, and our bed continues to work wonders (extra firm natural latex, thank goodness my wife likes that bed too 'cause it'll last us 30 years).
HRT has thrown a bit of a wrench in some aspects but aside from peeing a bit more it's been great on my health. I'm wondering if my reduction in eye floaters could even be linked.
So all told I have feel pretty happy. Hopefully I got mostly my maternal grandfather's longevity genes - man retired at 55 and lived to 102 doing fuck all physically. Didn't lose any of his mental capacity til he was nearing 100 and could walk up til near the end.
Edit: Guess I'll add Tinnitus last year, which I've mostly come to live with. Seemed to be brought on by stress (or non-zero chance of COVID infection in Feb 2020) and then transformed by eustachian tube misbehavior after going on HRT. Thankfully I've learned to manage with it and it's more annoying than troublesome.