The hardware itself may not be, but the software was still very unique and different from what others were doing. While everyone was going for realism to showcase tech, Zelda decided to go with a very child-like cell shaded style; Mario's new gameplay mechanic was a weird water pack; Smash Bros added Marth and Roy, Ice Climbers and freaking Game & Watch; Kirby in the GC was a racing game; Metroid went 3D and became a FPS more focused on exploration than actually shooting; DK games used a bongo controller lol.
They even debuted a bunch of franchises, most of them being extremely weird: Pikmin, Chibi Robo, Eternal Darkness, Odama, Cubivore, Giftpia, Densetsu Quiz, Geist. Had sequels for stuff like Custom Robo, Kururin, Wave Race, etc. And at the same time they had the GBA debuting series such as Golden Sun, Rhythm Heaven and Starfy.
Over the two systems, they pushed a lot of new IPs and experimented with their long running franchises.