How much am I missing by kinda ignoring the silkwire and/or wyvern-riding gameplay mechanics (or whatever it was called) in combat? I did the tutorial but it just felt clunky and annoying so while hunting I just played normally, but Mizu took me a fair bit to beat. >.> (Playing solo, don't have online with Nintendo)
I barely used the wirebug during my first few hunts and got by just fine, but it's definitely worth working the wirebug into your arsenal. The first thing you should get accustomed to is ZL+B to quickly recover when knocked down. It's saved me a few times, and it's just nice not spending so much time on my butt, heh.
Then, depending on the weapon, the silkbind attacks (ZL+X, ZL+A while unsheathed) can be worth it, even if you don't care about mounting the monster. In the demo, some silkbind attacks just do a bunch of "mounting" damage, but others provide buffs or have some special feature. For example the GS's power sheathe will boost attack for a short time, and the SnS's windmill will interrupt a monster's attack. The full game will let you choose the silkbind attacks in your loadout, so hopefully there's a good variety.
Finally, wiredashing (ZL+X, ZL+A while sheathed) can be useful in combat to close the gap, get aerial, and dodge attacks. I'm still getting used to this aspect. I have to consciously think about using ZL+X when Rathian goes airbourne, or ZL+A when the Mizutsune ends up a distance away. And I haven't worked it into my dodge instincts. Gotta keep practicing...