Personally, despite how Control is the hardest pill to swallow because it confirms that Illusive Man was at least partially correct on how the Reapers could be controlled, the Paragon version probably has the best possible outcome for the galaxy (yes, there is a difference between Paragon Control and Renegade Control). In Paragon Control, the reapers may protect the galaxy but they rebuild and probably fuck off. I would like to assume that after rebuilding, Paragon Shepard flew most of the Reapers straight into the nearest sun because that would match Paragon Shepard's personality in saying "yeah, technically TIM was right but this technology is based on the pain and suffering of countless races and it would be catastrophic if it fell into the wrong hands again."
Destroy seems like BioWare realized after the fact that people would overwhelmingly pick this option and then shoved in that last second "oh you'll genocide all of the synthetics if you do this." Destroy defenders can dance around this all they want, but picking Destroy under these terms might as well be somewhat buying into the Reaper's dumb-ass logic in that "well, might as well kill all synthetics because some of them are killing organics." And not recognizing the Geth as a sentient race after everything in these games might as well be tantamount to being like these old, stubborn Quarian folks who perpetuated this conflict for 500 years. Watch what happens when the galaxy does create the next line of synthetics and they find out what happened in the Destroy ending.
Synthesis is... weird... It takes the galaxy out of the Reaper's broken equation without their will, knowledge, or consent. Plus, that doesn't stop the Reapers from flying to another galaxy and repeating this same shit over there.
These endings are all terrible and directly go against prevalent themes across all games, but I feel like Paragon Control is the one true hope of breaking this cycle.