Araki has written about this iirc. He basically thinks one of the most evil acts a person can do is abuse animals, hence why he has villains doing so constantly lol.
Given how similar the "activation" is to Bites the Dust, I imagine they'll find a way around it somehow. Holly seemed to hint that the Doctor could be chased if the person doing so was guided to him, as opposed to actively seeking him out, so maybe this is where Yasuho's Stand will shine.
Given that Josuke has rock parts already, I just don't see him making it out alive, or at least in the current form. Maybe some other exchange occurs, but there is a lot of sacrificial themes in this part and I can see that theme continuing.
I am going to guess in the end he is going to use the fruit to save his mother but dies in the process