Two newbies who are in over their heads. One player focuses entirely on protecting the other and moving around heavy objects, the other has a means to weaken foes (such as an UV flashlight or some other conventional tool) so the other can do bonus damage, and is more limber, able to climb up to areas inaccessible to the other player.
No returning characters. There isn't a single main protagonist in the Resident Evil series who isn't a hardened badass by the end of their game. If they're a recurring protagonist, then they're even more ridiculous. Return to the RE7 style, where instead of some hardened counter-BOW operative or series veteran, it's a green, terrified, unprepared person who either brought the horror on themselves (RE7), or found themselves in that situation unwittingly (RE2).