Announced on the Take Two conference call.
What's surprising is that it is very much a consistent seller. It's the game of the generation with many buying the game when they pick up a current gen console.
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For reference. Minecraft is the best selling paid game when combining sales of the Console, PC and Mobile versions with over 150m sold. GTAV is second. GTAV has now sold more than GTA III, VC, SA, and IV combined.
(Tetris technically sold more than both titles when you combine all the versions of the game).
What this graph doesn't show is that unit price has fallen over time. I think wholesale price the game can be bought for around US$15/Eu15 on PC for a key at the moment. There's also been significantly more sales on steam recently than there's been in the past.
All that said, 100m is a incredible achievement, most of that due to GTA online, I don't think they could have achieved it if it was just a single player game.