Pretty much. The original movie worked because it a lightning in a bottle of a group of hilarious comedians in this inverse tone gloomy nyc, where they make ghost busting a exterminator type job.
I think it works because they built an entire world that works with different groups.
You can have different types of people with different tones to the work, but still keep proton packs, ghost traps, ECTO-1, Tobin's Spirit Guide. The movie's background flavor was almost too good for a comedy OR horror.