Given that the decade comprised at least half of the previous generation and all of the current one, sure.
TLOU, as a capstone to the previous generation, is basically a perfect compilation and look forward.
It merged a lot of the narrative design pieces other games were going for at that the end of last generation. Its rare that a standard bearer in a field, like ND was with Uncharted, takes a step further forward while most of the industry interested in that kind of design is still trying to catch their previous effort. For a generation like the last where narrative design/storytelling took such a big step forward being the game that capped and raised the bar further to close the gen. means quite a bit.
Then you have the gameplay, where ND successfully fused the emerging survivalist gameplay mechanics into the more familiar ground of third person cover shooters that were the hallmark of the PS360 libraries, and further layered in a very capable stealth mechanic (something developers still manage to fuck up today).
Best of all, the gameplay was paired with a range of difficulty and HUD costomizations that actually meaningfully impacted the gameplay. Not just "enemies deal more damage/you deal less damage" hooks. The "sonar" ability toggle completely reinvents the experience as the most obvious example.
So game of the generation for the last cycle was then, and is still today, a slam dunk for TLOU. That brings us to the current generation.
Most of the major AAA single player games of this gen. focused pretty heavily on chasing TLOU's design choices and style, succeeding with various degrees of success. I'd argue that its very telling when even in this thread the most noteworthy "successor" game is God of War, another Sony first party title. The previous generation Uncharted contenders, Tomb Raider most notably but also the AC games, etc. have all either failed to progress at the rate of Sony's first party teams or have moved away from those conventions in favor of more GAAS/open world RPG mechanics.
The only real competitor to me would be Breath of the Wild as its a daring reinvention of the franchises' present day form (at the time) that simultaneously calls back to the franchise's original roots. But BotW was a late dual platform release that had no real significance for the vast majority of the decade and has no been out long enough to where we can see that its impact on game design as a whole has been relatively minimal (at least within this decade).
The suggestion that any of the Souls games are worthy of consideration is, to put it blunt, an uninformed and invalid opinion. Demon's Souls was a 2009 game, as such entire concept of these games was birthed prior to this decade. The only ones that have deviated enough to merit consideration as something other than a direct successor to Demon's are Bloodborne and Sekiro. The fact that it took Dark Souls for PC and X360 players to see what From had created is simply not relevant. The explicit Souls games are not a creation of this decade, but one of the past that has matured this decade into a place of greater prominence. If someone wanted to argue that the follow up success of the Souls games makes Demon's Souls the retroactive game of the previous decade, missed at the time as we didn't know just how much it would take off, I'd probably agree. But unless you act like Japan didn't exist in 2009 the Souls "franchise" predates this decade and the franchise and associated mechanics are an integral part of its value as a "game of the decade" contender.