Oh, I wasn't weighing in on that convo. Just that animated human characters aren't meant to be 1:1 human (and often aren't despite themselves).
I think anime in particular has to deal with very human elements to qualify, but this varies person to person. I think of anime as a noun/adjective concerning a stylization of characters' models based on a lineage of Japanese animation tradition. So you can have "American anime," or "Canadian anime," or whatever if it's trying to ape the style. Secondly, I think of anime as an adjective concerning a laundry list of storytelling tropes found most prominently or made popular in Japanese animation. This can be anything from subject matter, to blocking, to even dialogue patterns (I can guarantee you many more Japanese games/shows mention "rendezvous points" than Western ones, for instance - a small but very anime thing to do in abundance). Thirdly, and most formally, I think of anime as a noun that refers strictly to an animated work that comes out of Japan.
That said, I think RE5 Chris punching boulders is very anime but I don't think his design is particularly. Not anymore than Gears of War characters are.