See this is why choosing that starting skill is going to be tough. In most any other RPG, something like Pain Threshold would just mean you have a higher defense stat, maybe
From early devblog on checks and skills
The sheer amount of potential inter-connectivity between skills based on that theoretical scenario seems kind of impossible to imagine devs actually achieving that.
From early devblog on checks and skills
So this is how we've re-thought passive checks. The versatility of this simple system – let me just repeat it one more time: YOUR SKILLS TALK TO YOU – is pretty incredible. It is hard for us to imagine writing the game without it already. We can do really weird stuff. Like Half Light – the skill that controls your adrenaline gland and your prey drive – can railroad you into a rage spiral where you hound an innocent suspect on something they clearly didn't do. And it takes another skill's intervention for you to get out of it. The next moment a skill can wildly expand the options you have avalable, for example: Drama whispers insane method acting ideas into your ear. Or your Pain Threshold tells you to stab yourself in the hand to make a point. Whatever you do – don't. Pain Threshold is an unstable masochist. It will only leave you screaming with your hand nailed to the table. And then – while screaming with your hand nailed to the table – Rhetoric to the rescue! Make a political point out of this. Tell them you're a victim of your own macho mentality. Tell them (with your hand still nailed to the table) that years of chauvinism have led you to this low point in your life.
The sheer amount of potential inter-connectivity between skills based on that theoretical scenario seems kind of impossible to imagine devs actually achieving that.