Overwhelming yes, but with an asterisk.
I did CBT therapy, meditation, and regular exercise for years. I had ambitions, but they felt unachievable due to environmental circumstances and often would my motivation for them would completely fade away. Eventually I found the subtler signs of depression like oversleeping, lack of motivation, and etc. were still causing me problems even though therapy and exercise had helped me learn to like myself. So I decided in July of this year to try it. At first I had the "Zombie" effect everyone talks about. I was pretty numb for a week or so. That subsided and I started to gradually feel like myself again. Around week 6 or 7 I was more or less feeling like me, though I'd describe my emotional range as having shifted. If it was a spectrum of 0-100, I'd say I'm now having 50 as my bottom and 80-90 as my top. Not bad all things considered.
That said, I think having done CBT and learning to like myself BEFORE trying medication, is why my medication worked so well. These things work in tandem with each other. The meds don't fix my mindset, but they allow me to use the techniques I learned in therapy more effectively and clear out the garbage in my mind.
I use Effexor XR, which my doctor suggested because I mentioned feeling a lack of energy. I'm happy to report that since starting medication I've had no bouts with depression, and anxiety has been significantly more manageable. And I'm actually achieving many of my goals which I thought were impossible given my environment.
I hope all of you find something that works for you.