I've been thinking about this since I started the game. Needing to eat/drink/sleep/urinate and defecate apart from the added bonuses those systems give you would add so much to the experience. I'm honeslty a bit disappointed that you can only drink monster and eat cryptobiotes, imagine having to actually pack and plan for food and shelter for your route, and added benefits/effects of certain food and drink. Could even add a morale meter to give further need for bathing and resting in private rooms rather than in the field.
The game already has a strong emphasis on logistics and preparedness, but outside some environments a few of the systems are just too easy to ignore. My favorite moments in the game have been when I'm struggling to truck through unfamiliar areas, not knowing how I'm going to make it to the delivery point and coming across a structure or item left behind by other porters that just barely give me what I need to scrape by.
The more in depth with upkeep systems the better in my opinion, especially for an optional mode. This style of gameplay has so much potential, and KojiPro has barely tapped the surface of what they could do with a game like this.