I try not to go over much longer than 24 hours anymore. Once did well over 48, with much hangover, then decided to do 2 small shrooms on NYE thinking I could handle it... Nah, ended up having a 10 second seizure right when the shrooms started to hit. My brain literally restarted like a PC, body convulsed - lol scared my tripping friends sober and lesson learned. I felt amazing afterward tho, so I guess my body handled that the best way it could.
Point of the story is, get your sleep. Your body needs it.