I think it's possible. Like I pointed out before, we had a senate runoff in GA beat the turnout of the 2016 Presidential elections. The old 'well, midterms the incumbant party gets creamed' math isn't the same.
Two years is far, but not that far away. Its not as if we won't still be dealing with covid, a shit economy, or the remenants of Trumpism then. Could work in either direction, but I think in the US we are past the whole idea of 'well, I am gonna vote for the other team this time around'. Politics have gotten way too polarized for that to be counted as anything close to a fact, we are in 'new normal' territory
As influential as Trump is I don't think he's enough to undo a trend that has been going for decades.
Covid will either make or break it. I could easily see a mobilization of the right in reaction to increased Covid restrictions as the media fuels the culture war.