It's certainly possible. From a design standpoint, you'd have to consider that any planned features/design would scale to portable mode as well, so it's possible it would have an effect on the overall design of the game. Then, depending on the scope of the game and the team resources, you optimize the game to best work in both docked and portable. Like, look at Ratchet and Clank: A Rift Apart, for example. A huge part of its design conceit is being able to seamlessly jump between worlds in seconds. Like, loading entire levels in seconds, and doing so again seconds later. If that game was coming to Switch, that simply wouldn't be possible, so the entire design of the game would have to be reworked. It would be a totally different game in scope and feel.